Speaker: Tomas Gedeon, Mathematics, Montana State University


Title: DSGRN: a bridge between network structure and network dynamics


Abstract: Dynamic Signatures Generated by Regulatory Networks (DSGRN) provides a queryable description of network dynamics over the parameter space. DSGRN is based on a new approach to dynamical systems, which moves the focus away from trajectories and invariant sets, and toward robust, scalable and computable description of dynamics in terms of lattices and posets. On the level of software, DSGRN takes as input a regulatory network and outputs a queryable SQL database that provides information about the structure of global dynamics over all of the associated parameter space. After introducing the main ideas of this new approach I will review applications to understanding of E2F-Rb network, to design of 3-node networks that function as switches, and to diagnosis of failure in synthetic biology.