November 1, 2007

October 25, 2007

GPCR Engineering Yields High-Resolution Structural Insights into ₂ Adrenergic Receptor Function

Daniel M. Rosenbaum, Vadim Cherezov, Michael A. Hanson, Sřren G. F. Rasmussen, Foon Sun Thian, Tong Sun Kobilka, Hee-Jung Choi, Xiao-Jie Yao, William I. Weis, Raymond C. Stevens, and Brian K. Kobilka
Published online October 25 2007; 10.1126/science.1150609 (Science Express Research Articles)
|  Abstract » |  PDF » |  Supporting Online Material »

High-Resolution Crystal Structure of an Engineered Human ₂-Adrenergic G Protein–Coupled Receptor

Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson, Sřren G. F. Rasmussen, Foon Sun Thian, Tong Sun Kobilka, Hee-Jung Choi, Peter Kuhn, William I. Weis, Brian K. Kobilka, and Raymond C. Stevens
Published online October 25 2007; 10.1126/science.1150577 (Science Express Research Articles)
|  Abstract » |  PDF » |  Supporting Online Material »

A Cosmic Microwave Background Feature Consistent with a Cosmic Texture

M. Cruz, N. Turok, P. Vielva, E. Martínez-González, and M. Hobson
Published online October 25 2007; 10.1126/science.1148694 (Science Express Reports)
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A Melanocortin 1 Receptor Allele Suggests Varying Pigmentation Among Neanderthals

Carles Lalueza-Fox, Holger Römpler, David Caramelli, Claudia Stäubert, Giulio Catalano, David Hughes, Nadin Rohland, Elena Pilli, Laura Longo, Silvana Condemi, Marco de la Rasilla, Javier Fortea, Antonio Rosas, Mark Stoneking, Torsten Schöneberg, Jaume Bertranpetit, and Michael Hofreiter
Published online October 25 2007; 10.1126/science.1147417 (Science Express Reports)
|  Abstract » |  PDF » |  Supporting Online Material »

Mnemonic Function of Lateral Prefrontal Cortex in Conflict-Induced Behavioral Adjustment

Farshad A. Mansouri, Mark J. Buckley, and Keiji Tanaka
Published online October 25 2007; 10.1126/science.1146384 (Science Express Reports)
|  Abstract » |  PDF » |  Supporting Online Material »

Hold Your Horses: Impulsivity, Deep Brain Stimulation, and Medication in Parkinsonism

Michael J. Frank, Johan Samanta, Ahmed A. Moustafa, and Scott J. Sherman
Published online October 25 2007; 10.1126/science.1146157 (Science Express Reports)
|  Abstract » |  PDF » |  Supporting Online Material »

October 18, 2007

A -Defensin Mutation Causes Black Coat Color in Domestic Dogs

Sophie I. Candille, Christopher B. Kaelin, Bruce M. Cattanach, Bin Yu, Darren A. Thompson, Matthew A. Nix, Julie A. Kerns, Sheila M. Schmutz, Glenn L. Millhauser, and Gregory S. Barsh
Published online October 18 2007; 10.1126/science.1147880 (Science Express Research Articles)
|  Abstract » |  PDF » |  Supporting Online Material »

A Bifunctional Bacterial Protein Links GDI Displacement to Rab1 Activation

Matthias P. Machner and Ralph R. Isberg
Published online October 18 2007; 10.1126/science.1149121 (Science Express Reports)
|  Abstract » |  PDF » |  Supporting Online Material »

Genome-Wide Experimental Determination of Barriers to Horizontal Gene Transfer

Rotem Sorek, Yiwen Zhu, Christopher J. Creevey, M. Pilar Francino, Peer Bork, and Edward M. Rubin
Published online October 18 2007; 10.1126/science.1147112 (Science Express Reports)
|  Abstract » |  PDF » |  Supporting Online Material »

October 11, 2007

The Genomic Landscapes of Human Breast and Colorectal Cancers

Laura D. Wood, D. Williams Parsons, Siân Jones, Jimmy Lin, Tobias Sjöblom, Rebecca J. Leary, Dong Shen, Simina M. Boca, Thomas Barber, Janine Ptak, Natalie Silliman, Steve Szabo, Zoltan Dezso, Vadim Ustyanksky, Tatiana Nikolskaya, Yuri Nikolsky, Rachel Karchin, Paul A. Wilson, Joshua S. Kaminker, Zemin Zhang, Randal Croshaw, Joseph Willis, Dawn Dawson, Michail Shipitsin, James K. V. Willson, Saraswati Sukumar, Kornelia Polyak, Ben Ho Park, Charit L. Pethiyagoda, P. V. Krishna Pant, Dennis G. Ballinger, Andrew B. Sparks, James Hartigan, Douglas R. Smith, Erick Suh, Nickolas Papadopoulos, Phillip Buckhaults, Sanford D. Markowitz, Giovanni Parmigiani, Kenneth W. Kinzler, Victor E. Velculescu, and Bert Vogelstein
Published online October 11 2007; 10.1126/science.1145720 (Science Express Research Articles)
|  Abstract » |  PDF » |  Supporting Online Material »

Orbital Reconstruction and Covalent Bondingat an Oxide Interface

J. Chakhalian, J. W. Freeland, H.-U. Habermeier, G. Cristiani, G. Khaliullin, M. van Veenendaal, and B. Keimer
Published online October 11 2007; 10.1126/science.1149338 (Science Express Research Articles)
|  Abstract » |  PDF » |  Supporting Online Material »

Widespread Morning Drizzle on Titan

Máté Ádámkovics, Michael H. Wong, Conor Laver, and Imke de Pater
Published online October 11 2007; 10.1126/science.1146244 (Science Express Reports)
|  Abstract » |  PDF » |  Supporting Online Material »