Rutgers University Department of Physics and Astronomy

2005-06 Handbook for Physics and Astronomy Graduate Students

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Research Programs


The recent technological advances in molecular biology forces us to take a more quantitative take on the subject. Mathematical and physical approaches in biology cover a wide variety of topics. They incorporate well established disciplines like molecular biophysics and structural biology to resurgent areas like system level dynamical analysis of biochemical networks. Rutgers faculty, in Physics and in other departments, are pursuing this approach to reach a deeper understanding of biology.

Professor Ronald M. Levy (Chemistry)

We use computer simulations and statistical mechanics to study thestructure, function, folding, and dynamics of proteins. Current researchprojects include the study of mechanisms for molecular recognition byproteins, homology modeling, and protein dynamics on longer time scales.We are interested in the interplay between computational models andexperimental studies of biological assemblies at different levels ofresolution. We are engaged in research in the area of ComputationalMolecular Biology - including the development of computational tools whichwill be useful for predicting the functions and structures of newlysequenced genes, as well as for studying the basic physical principles ofprotein folding.

Professor Wilma Olson (Chemistry)

Our research combines a variety of computational approaches (e.g.,Metropolis-Monte Carlo, energy minimization, polymer statistical mechanics,normal mode analysis) with developments in polymer theory to study thesequence,structure, properties, and function of nucleic acids at different levels ofresolution. Problems of current interest include: elastic models of the longthreadlike DNA double helix that account for its local structure, directrecognition, mesoscopic looping, supercoiling and knotting; conformationalchanges, including the overstretching and overtwisting of single molecules;electrostatic effects governing macromolecular structure and recognition;interactions with proteins, drugs, and carcinogens.

Professor Andrei Ruckenstein

Professor Anirvan Sengupta

Our research aims to understand information processing in the cellular enviroment. We are mostly focused on studying signaling and transcription. Our interests range from information theory of signaling cascades to bioinformatic tools for discovery of the transcriptional networks that affect gene expression as a result signaling events. We are also analyzing bistable genetic systems that can hold two different states for the same external cue. Currently, to complement our computational and theoretical work, we have set up a wet lab in the Waksman Institute to test our predictions and to generate data for further model building.

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Revised July, 2005